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Dr. Chitrala's Lab

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Publications

Peer-Reviewed Research Papers (Corresponding author*):

2023

  1. Inara Deedar Momin, Jessica Rigler, Kumaraswamy Naidu Chitrala*. Analysis of Potential Biomarkers in Frontal Temporal Dementia: A Bioinformatics Approach. J. Mol. Sci. 2023, 24(19), 14910.
  2. Vinay Jain, Divyashri Baraniya, Doaa E. Elhadedy, Tsute Chen, Michael J. Slifker, Fadhl Alakwaa, Kathy Q. Cai, Kumaraswamy Naidu Chitrala, Christopher Fundakowski. Integrative metatranscriptomic analysis reveals disease-specific microbiome-host interactions in oral squamous cell carcinoma. Cancer Research Communications. 2023; 3 (5): 807–820.
  3. Konstantin Golovine, Gleb Abalakov, Zhaorui Lian, Srinivas Chatla, Adam Karami, Kumaraswamy Naidu Chitrala, Jozef Madzo, Margaret Nieborowska-Skorska, Jian Huang, Tomasz Skorski. ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias. Blood Cancer Journal. 2023(13): 42 [Pubmed].
  4. Bo Zhou, Jayati Basu, Hasan Raza Kazmi, Kumaraswamy Naidu Chitrala, Xuan Mo, Sarah Preston-Alp, Kathy Q Cai, Dietmar Kappes, M Raza Zaidi. Interferon-gamma signaling promotes melanoma progression and metastasis. 2023 Jan;42(5):351-363 [Pubmed].

2022

  1. Umeshkumar Vekariya, Monika Toma, Margaret Nieborowska-Skorska, Bac Viet Le, Marie-Christine Caron, Anna-Mariya Kukuyan, Katherine Sullivan-Reed, Paulina Podszywalow-Bartnicka, Kumaraswamy Naidu Chitrala, Jessica Atkins, Malgorzata Drzewiecka, Wanjuan Feng, Joe Chan, Srinivas Chatla, Konstantin Golovine, Jaroslav Jelinek, Tomasz Sliwinski, Jayashri Ghosh, Ksenia Maslawska-Wasowska, Gurushankar Chandramouly, Reza Nejati, Mariusz Wasik, Stephen M. Sykes, Katarzyna Piwocka, Emir Hadzijusufovic, Peter Valent, Richard T. Pomerantz, George Morton, Wayne Childers, Huaqing Zhao, Elisabeth M. Paietta, Ross L. Levine, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Gaorav P. Gupta, Jean-Yves Masson, Tomasz Skorski. DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage. Blood. 2022 Dec 29 [Pubmed].
  2. Stavroula Kanoni, …, Kumaraswamynaidu Chitrala, …, Gina M Peloso. Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biol. 2022 Dec 27;23(1):268 [Pubmed].
  3. Scott Gross, Robert Hooper, Dhanendra Tomar, Alexander Armstead, Pranava Mallu, Hinal Joshi, Parkson Chong, Igor Astsaturov, Jeffrey Farma, Kumaraswamy Naidu Chitrala, John Elrod, M. Raza Zaidi, Jonathan Soboloff. Ca2+ signals suppress Melanoma Metastasis. EMBO J. 2022 Aug 30;e110046. doi: 10.15252/embj.2021110046 [Pubmed].
  4. Botong Shen, Dena Hernandez, Kumaraswamynaidu Chitrala, Marie Fanelli Kuczmarski, Nicole Noren Hooten, Natasha L. Pacheco, Nicolle A Mode, Ngozi Ezike, Alan B Zonderman. APOE gene region methylation is associated with cognitive performance in middle-aged urban adults. Neurobiology of Aging. 2022.116; 41–48 [Pubmed].
  5. Jnny shrestha, Maryline Santerre, charles NS Allen, Sterling P Arjona, Carmen Merali, Ruma Mukerjee, Kumaraswamy Naidu Chitrala, Jin Park, Asen bagashev, Elisio eugenin, Salim Merali, Marcus Kaul, Jeannie Chin, Bassel E Sawaya. HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein. Front Aging Neurosci. 2022 May 9;14:811481 [Pubmed].
  6. Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan. Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium. Nat Commun. 13, 2167. 2022 [Pubmed].
  7. Divyashri Baraniya, Kumaraswamy Naidu Chitrala, Nezar Noor Al-Hebshi. Global transcriptional response of oral squamous cell carcinoma cell lines to health-associated oral bacteria – an in vitro J Oral Microbiol. 2022 May 16;14(1):2073866 [Pubmed].
  8. Shweta Ramdas, …, Kumaraswamynaidu Chitrala, …, Christopher D Brown. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. American Journal of Human Genetics 109, 1366–1387. 2022

2021 

  1. Stavroula Kanoni, …, Kumaraswamynaidu Chitrala, …, Gina M Peloso. Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. medRxiv preprint. (doi: https://www.medrxiv.org/content/10.1101/2021.12.15.21267852v1).
  2. Sarah E Graham, …, Kumaraswamynaidu Chitrala, …, Cristen Willer. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021 [Pubmed].
  3. Ji Chen, …, Kumaraswamy N Chitrala, …, Inês Barroso. The Trans-Ancestral Genomic Architecture of Glycaemic Traits. Nat Genet. 2021 May 31 [Pubmed].
  4. Silvia Maifrede, …, Kumaraswamy N Chitrala, Tomasz Skorski. TET2 and DNMT3A mutations exert divergent effects on DNA Repair and sensitivity of leukemia cells to PARP Inhibitors. Cancer Res. 2021 Jul 2: canres.3761.2020 [Pubmed].
  5. Heming Wang, …, Kumaraswamy Naidu Chitrala, …., Diana van Heemst. Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Mol Psychiatry. 2021 Apr 15;10 [Pubmed].
  6. Kumaraswamy Naidu Chitrala*, Prakash Nagarkatti, Mitzi Nagarkatti. Deleterious single nucleotide polymorphisms in Catechol O-Methyltransferase confers risk to Post-traumatic stress disorder: A Molecular Dynamics Study. J Psychiatr Res. 2021, 38, 207-218 [Pubmed]
  7. Daokun Sun, …, Kumaraswamy Chitrala, …, Myriam Fornage. Multi-Ancestry Genome-wide Association Study Accounting for Gene-PsychosocialFactor Interactions Identifies Novel Loci for Blood Pressure Traits. HGG Adv. 2021 Jan 14;2(1):100013 [Pubmed]

 2020 

  1. Dragana Vuckovic, …, Kumaraswamy N. Chitrala, …, Vijay G. Sankaran, Nicole Soranzo. The Polygenic and Monogenic Basis of Blood Traits and Diseases. 2020, 182, 5, 1214-1231.e11 [Pubmed].
  2. Ming-Huei Chen, …, Kumaraswamynaidu Chitrala, …, Guillaume Lettre. Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations. 2020, 182, 5, 1198-1213.e14 [Pubmed].
  3. Haider Rasheed Alrafas, Philip Brandon Busbee, Kumaraswamy Naidu Chitrala, Mitzi Nagarkatti, Prakash Nagarkatti. Gut Dysbiosis Involving Increased Butyrate Production Provides Protection Against Colorectal Cancer Through Attenuation of Colonic Inflammation Resulting from Suppression of Histone Deacetylases. Clin. Med. 2020, 9(6), 1796 [Pubmed]
  4. Kumaraswamy N. Chitrala, Dena G. Hernandez, Michael A. Nalls, Nicolle A. Mode, Alan B. Zonderman, Ngozi Ejiogu, Michele K. Evans. Race-specific alterations in DNA methylation among middle-aged African Americans and Whites with Metabolic Syndrome. 2020 May;15(5):462-482 [Pubmed]

2019 

  1. Salman M. Tajuddin, Dena G. Hernandez, Brian H. Chen, Nicole Noren Hooten, Nicolle A. Mode, Mike A. Nalls, Andrew B. Singleton, Ngozi Ejiogu, Kumaraswamy N. Chitrala, Alan B. Zonderman, Michele K. Evans. Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and Whites. Clinical Epigenetics. 2019. 11:119 [Pubmed]
  2. Hirotaka Iwaki, , …, Kumaraswamy Naidu Chitrala, Mike A. Nalls. Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohorts. Mov Disord. 2019, 27845 [Pubmed]
  3. May A. Beydoun, Sharmin Hossain, Kumaraswamy Naidu Chitrala, Salman M. Tajuddin, Hind A. Beydoun, Michele K. Evans, Alan B. Zonderman. Association between epigenetic age acceleration and depressive symptoms in a prospective cohort study of urban-dwelling adults. J Affect Disord. 2019, 257, 64-73[Pubmed]
  4. Kumaraswamy Naidu Chitrala, Mitzi Nagarkatti, Prakash Nagarkatti, Suneetha Yeguvapalli. Analysis of the TP53 Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach. J. Mol. Sci. 2019, 20, 2962[Pubmed]
  5. Kumaraswamy Naidu Chitrala, Xiaoming Yang, Brandon Busbee, Narendra P. Singh, Laura Bonati, Yongna Xing, Prakash Nagarkatti. Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Sci Rep 2019 May 2;9(1):6810 [Pubmed]

2018

  1. Kumaraswamy Naidu Chitrala, Xiaoming Yang, Prakash Nagarkatti, Mitzi Nagarkatti. Comparative analysis of interactions between Aryl hydrocarbon receptor ligand binding domain with its ligands: A computational study. BMC Struct Biol 201818:15 [Pubmed]

 2017

  1. Pegah Mehrpouya-Bahrami, Chitrala Kumaraswamy Naidu, Mitra S. Ganewatta, Chuanbing Tang, E. Angela Murphy, Reilly T. Enos, Kandy T. Velazquez, Jamie McCellan, Mitzi Nagarkatti, Prakash Nagarkatti. Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity. Sci Rep 7: 15645 [Pubmed]
  2. Nagarjuna U, Madhusekhar M, Trinath D, Kumaraswamy Naidu C, Suneetha Y, Padmavathi V, Padmaja A. Synthesis, Characterization, Molecular Docking, Cytotoxic and Antioxidant Activities of Di(indolyl)thiazolylpyrazoles. Med Chem 2017, 7:11.
  3. Kumaraswamy Naidu Chitrala, Hongbing Guan, Narendra P. Singh, Brandon Busbee, Alexa Gandy, Pegah Mehrpouya-Bahrami, Mitra S. Ganewatta, Chuanbing Tang, Saurabh Chatterjee, Prakash Nagarkatti, Mitzi Nagarkatti. CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice. Eur J Immunol May 23 [Pubmed]
  4. Trinath, C. Kumaraswamy Naidu, P. Rishika, Y. Suneetha. Molecular screening and analysis of novel therapeutic inhibitors against c-Jun N-terminal kinase. Med Chem Res 2017. May pp 1–7: 10 [Springer]

Editorial Articles

  1. Chitrala Kumaraswamy Naidu. Mucosal immunology: an overview. J Mucosal Immunol Res 2017, 1:2.

Review Articles

  1. Chitrala Kumaraswamy Naidu, Yeguvapalli Suneetha. Current Knowledge on Microarray Technology an Overview. Tropical Journal of Pharmaceutical Research. February 2012; 11 (1): 153-164.

Book Chapters     

  1. C. Kumaraswamy Naidu, Y. Suneetha. Current status of Breast cancer in India. Cancer: Current and Future prospects. 2015; (1). ISBN 978-93-5174-071-1. 
  2. C. Kumaraswamy Naidu, Y. Suneetha, P. Naga Jyothi, M. Srinivasulu Reddy. Quantitative structure activity relationship of highly persistent pesticides. Frontiers in Aquaculture and Biotechnology, 2013; 245-251. ISBN: 978-81-925002-0-1.   
  3. C. Kumaraswamy Naidu, Y. Suneetha, P. Naga Jyothi. Role of bioinformatics in biodiversity. Threats to Biodiversity and Conservation policies, 2012.
  4. P. P. Mathur and C. Kumaraswamy Naidu. Biological Databases. Biotechnology: Concepts and Applications. Narosa publications, (India) 2009; 435 -461. ISBN: 978-81-7379-902-8.